Jan Fiedler studied biochemistry at the University of Bayreuth in between 2001 to 2006. His diploma thesis dealed with understanding mitochondrial morphogenesis in yeast. Moving to clinical applications, he performed his PhD thesis at the University Hospital Würzburg in experimental cardiology investigating RNA-based interventions for cardiac wounding and healing. After receiving his PhD in 2010 from the University of Würzburg he moved for Postdoc to Hannover Medical School where he built a research group on RNA therapeutics in cardiopulmonary disease.
He filed his Habilitation thesis (PD thesis) at Hannover Medical School in 2021 for experimental pharmacology on the subject of molecular mechanisms of non-coding RNA and its application in therapeutic intervention of heart failure. In 2021, Jan Fiedler started at Fraunhofer ITEM Hannover to initiate a cardiovascular research unit.