Dr. Olha Ivanova
CV: Ph.D in endocrinology, Kharkiv, V. Danilevsky Institute of Endocrine Pathology Problems of NAMS Ukraine, Kharkov, Ukraine, 2005 Current position: Senior Researcher in Laboratory of Biochemical Research at the V. Danilevsky Institute of Endocrine Pathology Problems of the National Academy of Medical Sciences of Ukraine, Kharkov, Ukraine.
Presentation title: SEX DIFFERENCES IN THE DEVELOPMENT OF DIABETIC CARDIOVASCULAR COMPLICATIONS IN RATS
Abstract: It was established that type 2 diabetes mellitus in rats more significant increases of glucose intolerance, insulin resistance, hypertriglyceridemia, and the level of total lipids in the liver of males compared to females. Type 2 diabetes increased more significant the level of lipid peroxidation products and decreased the total antioxidant activity of blood serum, which was accompanied by a more pronounced oxidative stress in the heart of diabetic males compared with females. Type 2 diabetes activates the antioxidant defense system in rat mitochondria in females and suppressed it in males. Type 2 diabetes more significantly decreases the activity of aconitase and succinate dehydrogenase in the heart mitochondria and activates of non-specific mitochondrial pores (mPTP) in males. It was shown that type 2 diabetes is accompanied by more pronounced disorders of the system of coagulation haemostasis and the development of myocardial diastolic dysfunction in females. The results indicate the perspectives of new methods development for prevention and treatment of diabetic cardiovascular complications, taking into account sexual dimorphism of major cardiovascular risk factors of type 2 diabetes mellitus.